Mechthild Lütge
Deciphering the molecular landscape of the stromal cells in human lymph nodes at the single-cell level
Sep 1, 2019
Fundamental Research - Sep 1, 2019 - Mar 31, 2025
Ongoing
Project leader: Ludewig Burkhard
Members: Stanossek Yves, Meili Samuel, De Martin Angelina, Lütge Mechthild, Kurz Lisa, Cheng Hung-Wei
Stromal Cell Niches at the Nexus of the Innate Lymphoid Cell Interactome
Jan 1, 2019Innate lymphoid cells (ILCs) critically impact a diverse array of diseases. While the main cell-intrinsic molecular pathways and some of the soluble mediators that regulate ILC development and their functional activity have been characterized, the ce...
Fundamental Research - Jan 1, 2019 - Dec 31, 2022
Automatically Closed
Project leader: Ludewig Burkhard
Members: Lütge Mechthild
Deciphering the transcriptomic landscape of cancer-associated fibroblasts in pancreatic cancer / Oncological Research
Jan 1, 2019Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancer types with a 5-year survival of only 7% and strongly limited treatment options. A major obstacle for successful treatment is the immunosuppressive nature of the tumor microe...
Fundamental Research - Jan 1, 2019 - Dec 31, 2021
Automatically Closed
Project leader: Ludewig Burkhard, Lütge Mechthild
Deciphering the transcriptomic landscape of cancer-associated fibroblasts in pancreatic cancer – an exploratory clinical study
Jul 1, 2018Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancer types with a 5-year survival of only 7% 1. While surgical resection of localized disease offers a moderate increase in survival, patients with metastatic pancreas cancer are...
Fundamental Research - Jul 1, 2018 - Dec 31, 2018
Completed
Project leader: Ludewig Burkhard
Members: Lütge Mechthild