Evaluation der Antibiotika-Resistenz von Helicobacter pylori Magen und Überprüfung der Konsistenz von Resistenzdaten aus dem Stuhl und aus Magenbiopsien

Clinical Studies - May 1, 2024 - Jun 30, 2025

Scheduled

Project leader: Kueres-Wiese Alexander
Members: Kuster Stefan, Frei Nicola Fabian, Borovicka Jan

Zur Optimierung des Antibiotikaverbrauchs wurde am Kantonsspital St.Gallen ein Antimicrobial Stewardship Programm (ASP) eingeführt. Für die erfolgreiche Umsetzung braucht es die aktive Einbindung aller beteiligten Fachpersonen über den gesamten Verso...

Healthcare Research - Dec 1, 2023 - Aug 31, 2024

Automatically Closed

Project leader: Künzler-Heule Patrizia
Members: Kohler Philipp, Kuster Stefan, Ledergerber Katrin, Flury Domenica, Schoop Barbara, Nicca D

Antineutrophil cytoplasmic antibodies (ANCA), especially PR3- and MPO-ANCA, are major biomarkers for the diagnosis of ANCA-associated vasculitis. Several recent studies suggested that PR3-ANCA may also be detected in 18–53% of patients with ulcerativ...

Clinical Studies - Jul 1, 2023 - Jul 1, 2025

Ongoing

Project leader: Truniger Samuel, Brand Stephan
Members: Koller Seraina, König Marius

This is a non-interventional prospective observational study in patients receiving Vedolizumab therapy for IBD. Sites will enroll patients with moderately to severely active IBD (UC or CD), initiating or ongoing IV induction treatment with vedolizu...

Clinical Studies - Jul 14, 2022 - Dec 31, 2023

Automatically Closed

Project leader: Brand Stephan
Members: Eckhold Annika, König Marius, Krieger-Grübel Claudia

A Phase 3, Multicenter, Open-Label, Long-Term Extension Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Patients with Crohn's Disease

Clinical Studies - Jun 7, 2022 - Dec 31, 2024

Ongoing

Project leader: Brand Stephan
Members: Eckhold Annika, Krieger-Grübel Claudia, König Marius

The Crohn’s disease exclusion diet (CDED) for induction and maintenance of remission in Crohn’s patients with or without additional medical therapy. An open label observational trial

Clinical Studies - Jun 1, 2022 - Dec 30, 2023

Automatically Closed

Project leader: Krieger-Grübel Claudia
Members: Brand Stephan, Eckhold Annika

This is a double-blind, randomised, multicentre, placebo-controlled, comparative phase IIb dose-finding and efficacy trial. The trial will be conducted with four treatment groups in the form of a parallel group comparison and will serve to compare...

Clinical Studies - Jun 1, 2022 - Dec 31, 2024

Ongoing

Project leader: Brand Stephan
Members: Eckhold Annika, König Marius, Krieger-Grübel Claudia, Truniger Samuel

A Phase 2, Multicenter, Dose-finding, Double blinded, Pla-cebo- Controlled Study to Evaluate the Safety and Effi-cacy of Efavaleukin Alfa Induc-tion Therapy in Patients with Mederatly to Severely UC

Clinical Studies - Apr 25, 2022 - Dec 31, 2023

Automatically Closed

Project leader: Brand Stephan
Members: Eckhold Annika, Krieger-Grübel Claudia

This is a national multi-center cohort confirmatory study which is designed as a prospective observational trial combined with retrospective data collection. Prospective data are collected through a patient questionnaire and assessment of blood sam...

Clinical Studies - Jan 20, 2022 - Mar 30, 2023

Automatically Closed

Project leader: Brand Stephan
Members: König Marius, Dütschler Joel, Krieger-Grübel Claudia, Eckhold Annika, Truniger Samuel, Frei Nicola Fabian, Albrich Werner

Phase 2, Multicenter, Clinical Study to Evaluate the Safety and Efficacy of MK-1308A (Coformulated MK-1308/MK-3475) in Combination with Lenvatinib (E7080/MK-7902) in First-line Therapy of Participants with Advanced Hepatocellular Carcinoma

Clinical Studies - Jul 3, 2021 - Dec 3, 2022

Automatically Closed

Project leader: Semela David
Members: Stillhard Roman, Bergamin Irina

A Phase 3b, Randomized, Double-Blind, Parallel-Arm, Placebo- and Active- Controlled Treat-Through Study of Mirikizumab and Vedolizumab in participants with Moderately to Severely Active Ulcerative Colitis

Clinical Studies - Feb 1, 2021 - Jan 1, 2024

Completed

Project leader: Brand Stephan
Members: Smolders Jolijn, Krieger-Grübel Claudia

A Phase 3, Multicenter, Open-Label Extension Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Patients with Moderately to Severely Active Ulcerative Colitis LUCENT 3

Clinical Studies - Jan 29, 2021 - Dec 1, 2024

Ongoing

Project leader: Brand Stephan
Members: Krieger-Grübel Claudia, Smolders Jolijn

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of Etrasimod in Adult Subjects with Eosinophilic Esophagitis

Clinical Studies - Oct 1, 2020 - Dec 1, 2022

Completed

Project leader: Brand Stephan, Smolders Jolijn

Clinical Studies - Aug 1, 2020 - Dec 31, 2029

Ongoing

Project leader: Bilz Stefan
Members: Semela David, Räss Andrea, Stillhard Roman

A Randomized, Controlled Phase 3 Study of Cabozantinib (XL184) in Combination with Atezolizumab versus Sorafenib in Subjects with Advanced Hepatocellular Carcinoma Who Have Not Received Previous Systemic Anticancer Therapy Randomisation 2:1:1:1 Cabo...

Clinical Studies - Sep 1, 2019 - Nov 28, 2020

Completed

Project leader: Semela David
Members: Stillhard Roman

A Phase 3 Double-blinded, Two-arm Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) versus Placebo as Adjuvant herapy in Participants ith Hepatocellular Carcinoma and Complete Radiological Response after Surgical esection or Local...

Clinical Studies - May 1, 2019 - May 1, 2026

Ongoing

Project leader: Semela David
Members: Stillhard Roman

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Induction Study to Evaluate the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects with Moderately to Severely Active Ulcerative Colitis

Clinical Studies - Jan 1, 2019 - Aug 1, 2020

Completed

Project leader: Sulz Michael
Members: Brand Stephan, Krieger-Grübel Claudia, Smolders Jolijn

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo- and Active- Controlled, Treat-Through Study to Evaluate the Efficacy and Safety of Mirikizumab in Patients with Moderately to Severely Active Crohn's Disease

Clinical Studies - Jan 1, 2019 - Dec 1, 2022

Automatically Closed

Project leader: Brand Stephan
Members: Sulz Michael, Smolders Jolijn, Krieger-Grübel Claudia

The primary objective of the study is to investigate, if the Supera® Peripheral Stent System has clinical superiority over EverFlex™ Self-Expanding Peripheral Stent System with Entrust™ Delivery System or as Protégé™ EverFlex™, a standard self-expand...

Clinical Studies - Jan 1, 2019 - Dec 31, 2025

Ongoing

Project leader: Hechelhammer Lukas
Members: Dick Florian, von Allmen Regula, Benecke Ulf, Baumer Andrea, Koeger Philipp, Stillhard Roman

Gallenpolypen stellen eine heterogene Entität dar. Einerseits kann es sich um Cholesterolpolypen ohne weiteren Krankheitswert handeln. Andererseits kann es sich um echte Adenome mit einem mit ihrer Grösse zunehmenden malignen Potential handeln. Zie...

Clinical Studies - Mar 1, 2018 - Dec 31, 2019

Automatically Closed

Project leader: Sawatzki Mikael, Baumeler Stephan