Thalidomide: from tragedy to promise

Publikation

Thalidomide: from tragedy to promise

Wissenschaftlicher Artikel/Review - 08.02.2003

von Moos Roger, Stolz Rahel, Cerny Thomas, Gillessen Sommer Silke

Zitation

von Moos R, Stolz R, Cerny T, Gillessen Sommer S. Thalidomide: from tragedy to promise. Swiss medical weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology 2003; 133:77-87.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Swiss medical weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology 2003; 133

Veröffentlichungsdatum

08.02.2003

ISSN (Druck)

1424-7860

Seiten

77-87

Kurzbeschreibung/Zielsetzung

Thalidomide is an immunomodulatory and antiangiogenic drug. Although the exact mechanism of action is not fully understood, it has been shown to be active in a variety of diseases. There are multiple trials going on to evaluate the optimal dose of thalidomide and the importance of combining thalidomide with other drugs. This review introduces the properties and putative mechanism of action of thalidomide and summarizes the most important clinical trials with this biological modifier.